PubMed Health⌕ Search

PubMed · 9550894

Lower limb ischemia.

Abstract

Diabetes mellitus is the major cause of nontraumatic amputations in the industrialized countries. In 1980 the scientific societies of diabetology and the patients' associations subscribed at St. Vincent a declaration together with the WHO, where a 50% decrease in amputations was among the primary objectives of clinical diabetology. The main cause of amputations is foot ischemia related to obliterating peripheral arterial disease, more diffuse and severe in diabetics, typically affecting the infrapopliteal vessels. Clinical patterns of foot ischemia include superficial necrotic areas and gangrene involving the entire foot with necrosis of all anatomic planes. Infection is a common complication with a negative impact on prognosis. Definitive treatment of ischemia is achieved with revascularization which at present due to the advances in diagnostic procedures can be performed in diabetics with the same effectiveness observed in non diabetics.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

G Ghirlanda, F Citterio. Lower limb ischemia.. https://pubmed.ncbi.nlm.nih.gov/9550894/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

evx1 transcription in bony fin rays segment boundaries leads to a reiterated pattern during zebrafish fin development and regeneration.

The dermoskeleton of zebrafish fins is composed of actinotrichia and segmented bony rays, or lepidotrichia, which grow by successive addition of distal segments. The present study shows that evx1, a new zebrafish even-skipped related gene (Thaëron et al., 2000) displays during bony ray morphogenesis, a unique repetitive expression pattern along the proximodistal axis of the fin. Whole-mount in situ hybridization performed on larvae and adult regenerating fins show that evx1 signal appears as parallel dash lines crossing the width of each developing and regenerating rays, in a ladder-like fashion. Cytological studies show that a subpopulation of bone forming cells (scleroblasts) expresses evx1 at the level of the joint between two adjacent segments except in the apical part of the differentiating ray where evx1 expression precedes the formation of the joint. This distal transcription is turned on again only when the latest differentiating segment reached its final size and might label the putative next segment boundary. This suggests the existence of a molecular mechanism controlling the periodic expression of evx1 which could be involved in the establishment of segment boundaries during fin ray morphogenesis, and could play a key role during dermal skeleton patterning.

Amputation, Surgical↗

Solitary renal cell carcinoma metastasis to the hand: the need for wide excision or amputation.

Metastatic renal cell carcinoma responds poorly to chemotherapy or radiation therapy and is associated with a dismal survival rate. In cases of a solitary acrometastasis, the literature supports complete resection of the lesion in an effort to prolong survival. We report a patient who presented with a solitary metachronous renal cell metastasis to the middle phalanx of the index finger. The lesion was correctly identified as a renal cell metastasis and aggressive surgical management was performed with curative intent.

Amputation, Surgical↗