PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 9552015

Supportive therapy in COPD.

T L Petty
View original source ↗Export metadata ↓

Abstract

Supportive therapy in COPD includes long-term oxygen therapy (LTOT) and patient support groups as two cornerstones in a comprehensive program of care known as pulmonary rehabilitation. The rich history of LTOT dating to the early 1960s and bolstered by excellent controlled clinical trials of the 1970s, along with additional advances, provided an effective therapy which improved both the quality and length of life in patients with COPD. Many patients with oxygen gain insight into coping with advanced COPD through patient support groups. The need for more cosmetically pleasing oxygen delivery systems to the nose, and future directions in providing oxygen in the home, remain challenges.

Explore related subjects

Adaptation, PsychologicalAmbulatory CareClinical Trials as TopicCombined Modality TherapyHumansLong-Term CareLung Diseases, ObstructiveOxygen Inhalation TherapySelf-Help GroupsSick RoleJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

T L Petty. 1998. Supportive therapy in COPD.. https://doi.org/10.1378/chest.113.4_supplement.256s

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2002

A generic model for changes in microbial kinetic coefficients.

Acclimation patterns in kinetic coefficients clearly demonstrate the limits of Monod's theory for the mathematical description of microbial growth. Focusing on E. coli grown under variable glucose levels, these patterns turn out to be highly diverse and sometimes even contradictory. Here, a new model based on an optimisation assumption is applied to a spectrum of adaptation phenomena, which are observed at steady-state as well as during transient situations. On the level of apparent kinetic coefficients, rates of adaptation are calculated depending on differential growth benefits. The resulting dynamics is bounded since maximum growth rate and substrate affinity are related by a non-linear trade-off. Long-term effects of phenotypic and genotypic changes under glucose limitation are robustly predicted by the model and explained in terms of their adaptive significance. Equivocal short-term recovery patterns occurring after sudden substrate excess are traced back to differences in the internal physiological state of the cells which in turn can be calculated in dependence on the inoculum history. Metabolic stress is a second determinant of short-term variations in kinetic coefficients which is here quantified in relation to external conditions as well as the internal state of cells. We demonstrate that lag phenomena and oscillations in anabolic activity exercised by E. coli under continuous growth acceleration can be reproduced without formulations being explicit in lag periods, metabolite concentrations or the timing of experimental changes. The overall predictive power of the simple approach indicates that slow as well as fast adjustments in apparent kinetic characteristics are strongly related to a dynamic optimisation strategy.

Adaptation, Psychological↗