Cell cycle control of DNA replication.

R Fotedar; A Fotedar

doi:10.1007/978-1-4615-1809-9_6

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PubMed · 9552354

Cell cycle control of DNA replication.

R Fotedar·A Fotedar

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Abstract

The cell cycle is driven by the sequential activation of a family of cyclin-dependent kinases (cdk), which phosphorylate and activate proteins that execute events critical to cell cycle progression. In mammalian cells cdk2-cyclin A has a role in S phase. Many replication proteins are potential substrates for this cdk kinase, suggesting that initiation, elongation and checkpoint control of replication could all be regulated by cdk2. The association of PCNA, a replication protein, with cdk-cyclins during G-1 to S phase transition and with cdk-cyclin inhibitors, adds an interesting complexity to regulation of DNA replication.

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Animals Cell Cycle Cell Cycle Proteins Cyclin-Dependent Kinases Cyclins DNA Replication DNA-Binding Proteins Enzyme Activation Humans Peptide Chain Elongation, Translational Peptide Chain Initiation, Translational Replication Protein A S Phase Journal Article Review

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R Fotedar, A Fotedar. 1995. Cell cycle control of DNA replication.. https://doi.org/10.1007/978-1-4615-1809-9_6

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