Intestinal cell cycle regulation.

T C Ko; W A Bresnahan; E A Thompson

doi:10.1007/978-1-4615-5371-7_4

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PubMed · 9552405

Intestinal cell cycle regulation.

T C Ko·W A Bresnahan·E A Thompson

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Abstract

The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-beta, which is expressed in the gut epithelium.

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Animals Cell Cycle Cell Differentiation Cell Division Cyclin-Dependent Kinases Cyclins Epithelial Cells Humans Intestines Mice Transforming Growth Factor beta Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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T C Ko, W A Bresnahan, E A Thompson. 1997. Intestinal cell cycle regulation.. https://doi.org/10.1007/978-1-4615-5371-7_4

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