Mos and the cell cycle.

B Singh; R B Arlinghaus

doi:10.1007/978-1-4615-5371-7_20

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PubMed · 9552420

Mos and the cell cycle.

B Singh·R B Arlinghaus

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Abstract

The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-regulatory role during meiosis. The Mos protein is required for the activation and stabilisation of M phase-promoting factor MPF. As a component of a large multiprotein complex known as the cytostatic factor (CSF), Mos is involved in causing metaphase II arrest of eggs in vertebrates. Upon expression in somatic cells, Mos causes cell cycle perturbations resulting in cytotoxicity and neoplastic transformation. All the known biological activities of Mos are mediated through activation of the mitogen activated protein (MAP) kinase pathway. Here we discuss the interrelationship between Mos and other cell cycle regulators.

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Animals Calcium-Calmodulin-Dependent Protein Kinases Cell Cycle Female Humans Maturation-Promoting Factor Microtubules Models, Biological Neoplasms Oocytes Phosphorylation Proto-Oncogene Mas Proto-Oncogene Proteins c-mos Proto-Oncogene Proteins c-raf Signal Transduction Journal Article Research Support, U.S. Gov't, P.H.S.Review

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B Singh, R B Arlinghaus. 1997. Mos and the cell cycle.. https://doi.org/10.1007/978-1-4615-5371-7_20

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