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Exploring development and disease through germ-line genetic engineering in the mouse.

R H Reeves
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Abstract

New developments in mouse genetics have transformed the field of genetics from a reactive to a proactive science. Current technologies in transgenesis, chromosome engineering, and saturation mutagenesis are introduced. These approaches permit the creation of new mutations and consequent mutant phenotypes that facilitate both the understanding of functions of existing genes and the search for previously unidentified genes affecting important phenotypes in all mammals.

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AnimalsDevelopmental BiologyGenetic Diseases, InbornGenetic EngineeringGerm-Line MutationMiceMice, TransgenicJournal ArticleReview

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R H Reeves. 1998. Exploring development and disease through germ-line genetic engineering in the mouse.. https://doi.org/10.1002/(sici)1097-0185(199802)253%3A1%3C19%3A%3Aaid-ar9%3E3.0.co%3B2-9

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