Protein folding: nucleation and compact intermediates.

O B Ptitsyn

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PubMed · 9556519

Protein folding: nucleation and compact intermediates.

O B Ptitsyn

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Abstract

Experimental and theoretical studies of protein folding have led now to understanding some basic principles of this process. In the simplest case of two-state folding it starts from the formation of the folding nucleus which immediately grows up embracing the whole protein molecule. However, typically folding occurs through a compact intermediate which has some native-like features of its 3D-structure. It is possible that also in these cases the folding nucleus is involved in the transition state between unfolded chain and compact intermediate.

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O B Ptitsyn. 1998. Protein folding: nucleation and compact intermediates.. https://pubmed.ncbi.nlm.nih.gov/9556519/

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