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PubMed · 9557221

Modelling the infundibulum in acne.

R Guy·T Kealey
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Abstract

The human sebaceous-pilosebaceous infundibulum was isolated and maintained for 7 days. Infundibular viability was maintained over 7 days in this medium. The addition of 1 ng/ml interleukin 1 alpha (IL-1 alpha) caused hypercornification of the infundibulum similar to that seen in comedones which could be blocked by 1,000 ng/ml IL-1 receptor antagonist. However, in contrast to interferon gamma 1, IL-1 alpha had no effect on the expression of intercellular adhesion molecule or human leucocyte antigen type DR in infundibular keratinocytes. The addition of 5 ng/ml epidermal growth factor or 5 ng/ml transforming growth factor alpha to the medium caused a disorganization of the keratinocytes of the infundibulum. We are now, therefore, able to model histologically the major infundibular changes in acne. Furthermore, we suggest that IL-1 alpha causes the scaling seen in many inflammatory skin diseases.

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Antigens, CDAntigens, DifferentiationCell Adhesion MoleculesCulture TechniquesEpidermal Growth FactorHLA-DR AntigensHair FollicleHumansIntercellular Adhesion Molecule-1Interferon-gammaInterleukin-1KeratinsSebaceous GlandsTransforming Growth Factor alphaJournal ArticleResearch Support, Non-U.S. Gov't

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R Guy, T Kealey. 1998. Modelling the infundibulum in acne.. https://doi.org/10.1159/000017862

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