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PubMed · 9558001

Tumor antigen presentation: changing the rules.

T D Armstrong·B A Pulaski·S Ostrand-Rosenberg
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Abstract

Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen dominates activation of tumor-specific CD4+ T cells. These results pose interesting paradoxes for the generation of immune responses, and have definite implications for the development of anti-cancer vaccines.

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AnimalsAntigen PresentationAntigens, NeoplasmCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCancer VaccinesDendritic CellsHistocompatibility Antigens Class IIHumansNeoplasmsTransfectionJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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T D Armstrong, B A Pulaski, S Ostrand-Rosenberg. 1998. Tumor antigen presentation: changing the rules.. https://doi.org/10.1007/s002620050463

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