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Stat3 activation is required for cellular transformation by v-src.

J F Bromberg·C M Horvath·D Besser·W W Lathem·J E Darnell
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Abstract

Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild-type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.

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3T3 CellsAnimalsCell SurvivalCell Transformation, NeoplasticDNA-Binding ProteinsGene Expression Regulation, NeoplasticMiceOncogene Protein pp60(v-src)STAT3 Transcription FactorStem CellsTrans-ActivatorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J F Bromberg, C M Horvath, D Besser, W W Lathem, J E Darnell. 1998. Stat3 activation is required for cellular transformation by v-src.. https://doi.org/10.1128/mcb.18.5.2553

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