Autoantigen Ku and its role in multiple cellular processes.

A K Ghosh

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PubMed · 9567759

Autoantigen Ku and its role in multiple cellular processes.

A K Ghosh

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Abstract

Ku is a DNA binding protein composed of 70 and 80 kDa subunits which was discovered as autoantigen in a patient with scleroderma-polymyositis overlap syndrome. Ku can bind to the end of DNA and also to some internal sequences. Ku-autoantigen acts as a potential transcription factor for several RNA polymerase II genes and RNA polymerase I gene. Ku is also associated with DNA-dependent protein kinase and involved in V(D)J recombination and DNA break repair mechanisms. Ku may be involved in replication, helicase activity and cell signaling. Therefore, Ku-autoantigen is a very important cellular factor which plays important role in the multiple cellular processes.

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Animals Antigens, Nuclear Autoantigens DNA Helicases DNA Repair DNA-Binding Proteins Humans Ku Autoantigen Nuclear Proteins Transcription Factors Journal Article Review

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A K Ghosh. 1997. Autoantigen Ku and its role in multiple cellular processes.. https://pubmed.ncbi.nlm.nih.gov/9567759/

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