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Redundant down-regulation pathways for p53.

M Cinelli·L Magnelli·V Chiarugi
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Abstract

The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and active p53 isoforms. The mechanisms prolonging p53 half life, following irradiation, are also discussed.

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AnimalsDown-RegulationGene Expression RegulationHumansIsomerismTumor Suppressor Protein p53Journal ArticleResearch Support, Non-U.S. Gov'tReview

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M Cinelli, L Magnelli, V Chiarugi. 1998. Redundant down-regulation pathways for p53.. https://doi.org/10.1006/phrs.1997.0269

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