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PubMed · 9573303

Human immunodeficiency virus type 2 Vpx-Gag interaction.

H A Pancio·L Ratner
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Abstract

Incorporation of Vpx into human immunodeficiency virus type 2 (HIV-2) virus-like particles is mediated by the Gag polyprotein. We have identified residues 15 to 40 of Gag p6 and residues 73 to 89 of Vpx as being necessary for virion incorporation. In addition, we show enhanced in vitro binding of Vpx to a chimeric HIV-1/HIV-2 Gag construct containing residues 2 to 49 of HIV-2 p6 and demonstrate that the presence of residues 73 to 89 of Vpx allows for in vitro binding to HIV-2 Gag.

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Amino Acid SequenceBinding SitesHIV Core Protein p24HIV-2HumansMolecular Sequence DataRetroviridae ProteinsViral Regulatory and Accessory ProteinsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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H A Pancio, L Ratner. 1998. Human immunodeficiency virus type 2 Vpx-Gag interaction.. https://doi.org/10.1128/jvi.72.6.5271-5275.1998

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