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How the MHC selects Th1/Th2 immunity.

J S Murray
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Abstract

While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it is less clear why a dichotomy of effector cytokine production would initiate from antigen-specific lymphocytes. Nevertheless, in defined experimental systems, the interaction between T-cell receptor (TCR), peptide and major histocompatibility complex (MHC) can determine Th1/Th2 dominance. Here, Joseph Murray discusses how TCR affinity and ligand density might interface with innate forces in the selection of CD4+ T-cell functions.

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AnimalsHumansImmunity, CellularMajor Histocompatibility ComplexMiceTh1 CellsTh2 CellsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Review

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J S Murray. 1998. How the MHC selects Th1/Th2 immunity.. https://doi.org/10.1016/s0167-5699(97)01237-1

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