Solubilization of diazepam.

F A Alvarez Núñez; S H Yalkowsky

PubMed · 9580239

Solubilization of diazepam.

Abstract

Several attempts to increase diazepam solubility are in the literature. This study discusses these different solubilization approaches. Specific reference is given to the rationale in the application of pH control, cosolvency, surfactants, and cyclodextrins. It was found than cosolvency is a more attractive means of solubilizing diazepam than either pH control, surfactants, or cyclodextrins. Advantages, assumptions, and limitations of these diazepam solubilization techniques are also described.

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Anti-Anxiety Agents Cyclodextrins Diazepam Hydrogen-Ion Concentration Solubility Surface-Active Agents Journal Article

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F A Alvarez Núñez, S H Yalkowsky. Solubilization of diazepam.. https://pubmed.ncbi.nlm.nih.gov/9580239/

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