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PubMed · 9588097

[Hypertonic-hyperoncotic volume replacement with Tensitone].

L Vokrouhlický·R Soucek
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Abstract

BACKGROUND: The use of hypertonic-hyperoncotic solutions (HHS) is a modern method of volume restoration in hypovolaemias of different etiology. The objective of the present work was to evaluate the effectiveness and safety of the hypertonic-hyperoncotic plasma expander Tensitone (7.5% NaCl in 6% dextran 70, Infusia a.s., CR) in patients with a massive acute blood loss. METHODS AND RESULTS: In a multicentre clinical study the authors investigated the effect of a rapid infusion of a small volume of tensitone (4 ml/kg) on the restoration of basic haemodynamic parameters, diuresis and the general condition of 81 patients with massive traumatic or peroperative haemorrhage. As compared with the effect of standard volume expanders (N = 34), Tensitone had a markedly more rapid and more pronounced effect on the normalization of the blood pressure (p < 0.01), heart rate (p < 0.05), central venous pressure and diuresis (p < 0.01). The haemodynamic effects of Tensitone are almost immediate (rise of blood pressure within 10 minutes) while they are at the same time sufficiently protracted (for at least 2 hours). The tolerance and safety of treatment were very good, more serious undesirable effects (thrombophlebitis) were recorded only in 3.6% of the patients. CONCLUSIONS: Tensitone is an effective and safe preparation for rapid small volume resuscitation. Its use is consistent with modern trends in intensive care and acute medicine.

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AdultDextransFemaleHemodynamicsHemorrhageHumansInfusions, IntravenousMaleMiddle AgedPlasma SubstitutesSodium ChlorideSolutionsClinical TrialControlled Clinical TrialJournal ArticleMulticenter StudyResearch Support, Non-U.S. Gov't

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BibTeXRIS

L Vokrouhlický, R Soucek. 1998-03-09. [Hypertonic-hyperoncotic volume replacement with Tensitone].. https://pubmed.ncbi.nlm.nih.gov/9588097/

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