Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.

J C Wijkmans; A J Culshaw; A D Baxter

doi:10.1023/a:1009654412641

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Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.

J C Wijkmans·A J Culshaw·A D Baxter

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Abstract

4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be obtained. Further elaboration of immobilized biaryl ethers demonstrates the potential for combinatorial library generation.

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Ethers Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Nitrobenzoates Phenols Resins, Plant Journal Article

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J C Wijkmans, A J Culshaw, A D Baxter. Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.. https://doi.org/10.1023/a%3A1009654412641

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