Leukemogenesis: small differences in Myb have large effects.

T Graf

doi:10.1016/s0960-9822(98)70220-9

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Leukemogenesis: small differences in Myb have large effects.

T Graf

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Abstract

The avian retroviruses E26 and AMV carry mutated versions of the gene encoding the cellular transcription factor c-Myb. Surprisingly, these two mutant forms of Myb differ in the subsets of myeloid cells that they transform, the target genes that they activate, and the way in which they are regulated.

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Animals Avian Myeloblastosis Virus Carrier Proteins Cell Differentiation Cell Transformation, Viral Peptidyl-Prolyl Isomerase F Cyclophilins Gene Expression Regulation Genetic Vectors Mutation Peptidylprolyl Isomerase Proto-Oncogene Proteins Proto-Oncogene Proteins c-myb Retroviridae Trans-Activators Journal Article Review

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T Graf. 1998-05-07. Leukemogenesis: small differences in Myb have large effects.. https://doi.org/10.1016/s0960-9822(98)70220-9

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