Transcriptional control during T-cell development.

H Clevers; P Ferrier

doi:10.1016/s0952-7915(98)80245-8

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Transcriptional control during T-cell development.

H Clevers·P Ferrier

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Abstract

During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression.

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Animals Cell Differentiation Genes, Regulator Humans Mice T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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H Clevers, P Ferrier. 1998. Transcriptional control during T-cell development.. https://doi.org/10.1016/s0952-7915(98)80245-8

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