T lymphocyte differentiation in the periphery.

K M Murphy

doi:10.1016/s0952-7915(98)80253-7

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T lymphocyte differentiation in the periphery.

K M Murphy

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Abstract

The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4+ T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-gamma gene expression and clarification of the action of the new cytokine IL-18.

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Animals Cell Differentiation Cytokines Gene Expression Regulation Humans Interferon-gamma Interleukin-18 Interleukin-4 Mice Receptors, Interleukin Receptors, Interleukin-12 T-Lymphocytes Th1 Cells Th2 Cells Journal Article Review

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K M Murphy. 1998. T lymphocyte differentiation in the periphery.. https://doi.org/10.1016/s0952-7915(98)80253-7

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