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An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation.

M E García-Ojeda·S Dejbakhsh-Jones·I L Weissman·S Strober
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Abstract

In the principal pathway of alpha/beta T cell maturation, T cell precursors from the bone marrow migrate to the thymus and proceed through several well-characterized developmental stages into mature CD4+ and CD8+ T cells. This study demonstrates an alternative pathway in which the bone marrow microenvironment also supports the differentiation of T cell precursors into CD4+ and CD8+ T cells. The marrow pathway recapitulates developmental stages of thymic maturation including a CD4+CD8+ intermediary cell and positive and negative selection, and is strongly inhibited by the presence of mature T cells. The contribution of the marrow pathway in vivo requires further study in mice with normal and deficient thymic or immune function.

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AnimalsBiomarkersBone Marrow CellsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Culture TechniquesCell DifferentiationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesThymus GlandJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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M E García-Ojeda, S Dejbakhsh-Jones, I L Weissman, S Strober. 1998-06-01. An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation.. https://doi.org/10.1084/jem.187.11.1813

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