PubMed Health⌕ Search

PubMed · 9612758

[Jet lag].

Abstract

Desynchronization of circadian rhythmicity resulting from rapid travel through at least four time zones leads to symptoms known in everyday English as jet-lag. The most detrimental effect of jet-lag is fatigue with poor alertness and psychomotor performance. Severity is subject to individual variation in susceptibility (morning/evening typology, age,...) and environmental factors (direction of travel, number of time zones crossed, psychosocial environment...). Many measures used to prevent or reduce jet lag are inappropriate or ineffective and some may even be dangerous, such as use of melatonin. One of the most reliable preventive techniques consists of reinforcing social synchronizers by maintaining exposure to sunlight and social activity. Only two drugs currently available on the market can be recommended, i.e. non-benzodiazepinic hypnotics which induce high quality sleep to allow quick recovery and a new time-release caffeine agent which has been shown to prolong psychomotor performance.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D Lagarde, P Doireau. 1997. [Jet lag].. https://pubmed.ncbi.nlm.nih.gov/9612758/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

The crystal structure of anhydrous beta-caffeine as determined from X-ray powder-diffraction data.

The crystal structure of the low-temperature form of anhydrous caffeine has been determined by using X-ray powder-diffraction data with a combined simulated-annealing/Rietveld method. Anhydrous caffeine crystallizes with five crystallographically independent molecules in a monoclinic C-centred unit cell with dimensions of a=43.0390(17), b=15.0676(6) and c=6.95314(14) A and a beta angle of 99.027(2) degrees.

Caffeine↗

Variability in human skin permeability in vitro: comparing penetrants with different physicochemical properties.

Appreciating and compensating for the inherent variability associated with percutaneous absorption is essential in optimizing (trans)dermal therapy. In this study, the variability in human skin permeability associated with model penetrants of differing lipophilicity (caffeine (CF), methyl paraben (MP), and butyl paraben (BP)) was examined in a standardized intra-laboratory study (Franz cell experiments) using epidermal tissue from various donors. Experimentally derived permeability coefficients (K(P)) were also compared to that derived from two skin permeation models namely, Potts & Guy and Robinson (revised) models in order to further validate the Franz diffusion method employed and also elucidate the potential permeation pathway(s) employed by the model penetrants. Intra-subject variability associated with skin permeation of the model penetrants was generally found to be lower than inter-subject variability. Experimental K(P) values were found to be the same order of magnitude as predicted by the mathematical models. Calculated residual variance suggested the Potts and Guy's model to be relatively accurate in predicting skin permeability of the two parabens whilst the Robinson (revised) model was more effective for CF. The high variability in CF permeation compared to the parabens may suggest the in vitro skin permeation of solutes becomes more sensitive to intra- and/or inter-subject variation in skin lipid content, appendageal density, and imperfections (pores, cracks) as the hydrophilic nature of the solute increases. Such variability in skin permeability suggests a difference in CF permeation kinetics relative to the parabens. As such when performing in vitro drug permeation studies, it is essential that the variability in the absorption of the model permeants, according to their physicochemical properties, is considered when they are used to normalize or standardize any resulting data.

Caffeine↗