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PubMed · 9612801

Muscle maturation: implications for gene therapy.

J C van Deutekom·E P Hoffman·J Huard
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Abstract

Skeletal muscle is a promising target tissue for gene therapy, for both muscle and non-muscle disorders. A variety of methods have been studied to transfer genes into skeletal muscle, including retroviral, adenoviral and herpes simplex viral vectors. However, various factors impede muscle-based viral gene therapy. Here, we discuss why some viral vectors cannot efficiently transduce mature muscle fibers, and describe some new approaches to overcome this barrier.

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AnimalsGene Transfer TechniquesGenetic TherapyGenetic VectorsHumansMiceMuscle DevelopmentMuscle Fibers, SkeletalMuscle, SkeletalMuscular DystrophiesMuscular Dystrophy, AnimalVirusesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

J C van Deutekom, E P Hoffman, J Huard. 1998. Muscle maturation: implications for gene therapy.. https://doi.org/10.1016/s1357-4310(98)01231-3

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