Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation.

M Aiello; O Moran; M Pisciotta; F Gambale

doi:10.1007/s002490050127

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Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation.

M Aiello·O Moran·M Pisciotta·F Gambale

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Abstract

Interaction of the calcium-channel antagonist dihydropyridines (DHPs), lacidipine and nifedipine, with a phospholipid bilayer was studied using 600 ps molecular dynamic simulations. We have constructed a double layer membrane model composed of 42 dimirystoyl-phosphatidylcholine molecules. The DHP molecules locate at about 7 A from the centre of the membrane, inducing an asymmetry in the bilayer. While lacidipine did not induce significant local perturbations as judged by the gauche-trans isomerisation rate, nifedipine significantly decreased this rate, probably by producing a local rigidity of the membrane in the vicinity of the DHP.

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Calcium Channel Blockers Dihydropyridines Dimyristoylphosphatidylcholine Lipid Bilayers Models, Molecular Molecular Conformation Molecular Structure Nifedipine Phospholipids Stimulation, Chemical Thermodynamics Journal Article Research Support, Non-U.S. Gov't

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M Aiello, O Moran, M Pisciotta, F Gambale. 1998. Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation.. https://doi.org/10.1007/s002490050127

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