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PubMed · 9619425

Porous polyglycolide.

M Epple·O Herzberg
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Abstract

The solid-state polymerization of halogenoacetates leads quantitatively to polyglycolide (polyglycolic acid) and an eliminated metal halide. Washing out this salt leaves highly porous polyglycolide (total pore volume about 50%) with pore sizes in the submicron range. Thorough examination of the product with different methods (DSC, IR, and X-ray diffraction) gave no indication of any remaining halogenoacetate. This distinct micromorphology should be advantageous for its application as a biomaterial. Special features of porous polyglycolide are an inherent surface roughness, a high specific surface, a higher gas permeability, and a lower density compared to conventionally prepared polyglycolide. The control over these properties should allow a fine-tuning of the biocompatibility of polyglycolide.

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Biocompatible MaterialsCalorimetry, Differential ScanningMicroscopy, Electron, ScanningPolyglycolic AcidPorositySpectrum AnalysisJournal ArticleResearch Support, Non-U.S. Gov't

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M Epple, O Herzberg. 1998. Porous polyglycolide.. https://doi.org/10.1002/(sici)1097-4636(199822)43%3A2%3C83%3A%3Aaid-jbm1%3E3.0.co%3B2-h

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