Theoretical descriptors in quantitative structure-affinity and selectivity relationship study of potent N4-substituted arylpiperazine 5-HT1A receptor antagonists.

M C Menziani; P G De Benedetti; M Karelson

doi:10.1016/s0968-0896(98)00008-x

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Theoretical descriptors in quantitative structure-affinity and selectivity relationship study of potent N4-substituted arylpiperazine 5-HT1A receptor antagonists.

M C Menziani·P G De Benedetti·M Karelson

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Abstract

The ability of ad hoc defined size and shape descriptors and theoretical descriptors derived on a single structure to give powerful interpretative and predictive QSAR models has been compared and evaluated with respect to the quality of the pharmacological data available for a series of structurally diverse 5-HT1A receptor antagonists, displaying selectivity towards the alpha 1-adrenergic receptor.

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Molecular Structure Piperazines Receptors, Serotonin Receptors, Serotonin, 5-HT1 Serotonin Antagonists Structure-Activity Relationship Journal Article

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M C Menziani, P G De Benedetti, M Karelson. 1998. Theoretical descriptors in quantitative structure-affinity and selectivity relationship study of potent N4-substituted arylpiperazine 5-HT1A receptor antagonists.. https://doi.org/10.1016/s0968-0896(98)00008-x

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