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PubMed · 9630607

Dendritic alterations in cortical pyramidal cells in the sparse fur mouse.

K J Hopkins·J McKean·R F Mervis·M L Oster-Granite
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Abstract

Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur (spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in spf/Y mice.

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AnimalsCell SizeCerebral CortexDendritesMaleMiceMice, Mutant StrainsOrnithine CarbamoyltransferasePyramidal CellsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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K J Hopkins, J McKean, R F Mervis, M L Oster-Granite. 1998-06-22. Dendritic alterations in cortical pyramidal cells in the sparse fur mouse.. https://doi.org/10.1016/s0006-8993(98)00392-8

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