F-actin-binding proteins.

A McGough

doi:10.1016/s0959-440x(98)80034-1

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F-actin-binding proteins.

A McGough

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Abstract

The study of proteins that bind filamentous actin (F-actin) is entering an exciting stage as more and more structures are determined. After more than 50 years in which the focus was on muscle proteins, emphasis has recently shifted towards understanding the complex interplay among actin-binding molecules in non-muscle cells. To date, the binding sites for eight classes of filament-binding molecules have been determined by combining low- to intermediate-resolution maps obtained by electron microscopy with atomic structures determined by X-ray crystallography and NMR. Recent results have dramatically accentuated the importance of filament geometry and actin conformation in defining these interactions.

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Actin Depolymerizing Factors Actins Animals Binding Sites Carrier Proteins Cross-Linking Reagents Crystallography, X-Ray Gelsolin Macromolecular Substances Microfilament Proteins Microscopy, Electron Models, Molecular Muscle Contraction Protein Binding Journal Article Research Support, Non-U.S. Gov't Review

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A McGough. 1998. F-actin-binding proteins.. https://doi.org/10.1016/s0959-440x(98)80034-1

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