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Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system.

M D Waldinger·H H Berendsen·B F Blok·B Olivier·G Holstege
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Abstract

Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

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AnimalsEjaculationHumansMaleSerotoninSelective Serotonin Reuptake InhibitorsJournal ArticleReview

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M D Waldinger, H H Berendsen, B F Blok, B Olivier, G Holstege. 1998. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system.. https://doi.org/10.1016/s0166-4328(97)00183-6

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