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PubMed · 9641797

Cytokines and cognitive function in mice.

M Bianchi·P Sacerdote·A E Panerai
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Abstract

A bidirectional flow of informations exists between the central nervous system and the immune system. Cytokines play a crucial role in this communication and exert several neuromodulatory actions. This short review considers some data concerning the effects of several cytokines, interleukin (IL)-1, IL-2, IL-6 and granulocyte-macrophage colony-stimulating factor on scopolamine-induced amnesia for a passive avoidance response, and on hippocampal neurotransmitter amino acid levels in mice. We interpret these behavioral and biochemical observations to indicate that the cytokine-to-brain communication can result in alterations in brain functions.

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AmnesiaAnimalsAvoidance LearningCognitionCytokinesGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-1Interleukin-6MaleMiceMice, Inbred StrainsRecombinant ProteinsScopolamineJournal Article

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M Bianchi, P Sacerdote, A E Panerai. Cytokines and cognitive function in mice.. https://doi.org/10.1159/000014527

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PubMed2007

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