Does disparate occurrence of autoregulatory programmed frameshifting in decoding the release factor 2 gene reflect an ancient origin with loss in independent lineages?

B C Persson; J F Atkins

doi:10.1128/jb.180.13.3462-3466.1998

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Does disparate occurrence of autoregulatory programmed frameshifting in decoding the release factor 2 gene reflect an ancient origin with loss in independent lineages?

B C Persson·J F Atkins

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Abstract

In Escherichia coli an autoregulatory mechanism of programmed ribosomal frameshifting governs the level of polypeptide chain release factor 2. From an analysis of 20 sequences of genes encoding release factor 2, we infer that this frameshift mechanism was present in a common ancestor of a large group of bacteria and has subsequently been lost in three independent lineages.

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Amino Acid Sequence Bacteria Base Sequence Conserved Sequence Evolution, Molecular Frameshift Mutation Homeostasis Molecular Sequence Data Peptide Termination Factors Phylogeny Ribosomes Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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B C Persson, J F Atkins. 1998. Does disparate occurrence of autoregulatory programmed frameshifting in decoding the release factor 2 gene reflect an ancient origin with loss in independent lineages?. https://doi.org/10.1128/jb.180.13.3462-3466.1998

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