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PubMed · 9645224

The structure and function of platelet-activating factor acetylhydrolases.

Z S Derewenda·U Derewenda
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Abstract

Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique and biologically important family of phospholipase A2s. They are related to neither the well-characterized secretory nor cytosolic PLA2s, and unlike them do not require Ca2+ for catalytic activity. The distinguishing property of PAF-AHs is their unique substrate specificity: they act on the phospholipid platelet-activating factor (PAF), and in some cases on proinflammatory polar phospholipids, from which they remove a short acyl moiety--acetyl in the case of PAF--located at the sn-2 position. Because PAF is found both in the plasma and in the cytosol of many tissues, PAF-acetylhydrolases are equally widely distributed in an animal organism. Recent crystallographic studies shed new light on the complex structure-function relationships in PAF-AHs.

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1-Alkyl-2-acetylglycerophosphocholine EsteraseAnimalsHumansModels, ChemicalModels, MolecularPhospholipases APlatelet Activating FactorStructure-Activity RelationshipJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Z S Derewenda, U Derewenda. 1998. The structure and function of platelet-activating factor acetylhydrolases.. https://doi.org/10.1007/s000180050172

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1-Alkyl-2-acetylglycerophosphocholine Esterase↗
PubMed2007

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1-Alkyl-2-acetylglycerophosphocholine Esterase↗
PubMed2007

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1-Alkyl-2-acetylglycerophosphocholine Esterase↗