tRNA mimics.

R Giegé; M Frugier; J Rudinger

doi:10.1016/s0959-440x(98)80060-2

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tRNA mimics.

R Giegé·M Frugier·J Rudinger

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Abstract

Mimics recapitulating the structural features of tRNAs are involved in biological processes other than ribosome-dependent protein synthesis. A knowledge of the rules underlying the architecture and function of tRNAs allows the design of non-natural mimics. The study of these mimics sheds light upon links between replication, translation and metabolic pathways, leads to biotechnological applications, and provides experimental and conceptual tools for the exploration of primordial evolutionary processes.

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Animals Base Sequence DNA Replication Drug Design Humans Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Protein Conformation RNA, Transfer Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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R Giegé, M Frugier, J Rudinger. 1998. tRNA mimics.. https://doi.org/10.1016/s0959-440x(98)80060-2

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