Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

C E Pearson; R R Sinden

doi:10.1016/s0959-440x(98)80065-1

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PubMed · 9666328

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

C E Pearson·R R Sinden

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Abstract

Models for the disease-associated expansion of (CTG)n.(CAG)n, (CGG)n.(CCG)n, and (GAA)n.(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand structures that may be important intermediates and result in their genetic instability.

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Base Composition Base Sequence DNA DNA Repair DNA Replication Genetic Diseases, Inborn Humans Models, Genetic Models, Molecular Mutation Nucleic Acid Conformation Recombination, Genetic Thermodynamics Trinucleotide Repeats Journal Article Review

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C E Pearson, R R Sinden. 1998. Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.. https://doi.org/10.1016/s0959-440x(98)80065-1

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