Substance P-induced depolarization accompanied by a decrease in membrane input resistance in the hamster submandibular ganglion cell.

T Soejima; T Endoh; T Suzuki

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PubMed · 9667145

Substance P-induced depolarization accompanied by a decrease in membrane input resistance in the hamster submandibular ganglion cell.

T Soejima·T Endoh·T Suzuki

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Abstract

We described in a previous paper (Bull Tokyo dent Coll 33: 33-35, 1992) that the submandibular ganglion cells (SMG) of hamster responded to substance P (SP) with a depolarization, which could be divided into three subtypes according to the change in membrane input resistance (Rm) during depolarization: depolarizations accompanied by either an increase or a decrease in Rm, and without change in Rm. In this study, the generation mechanism of the SP-induced depolarization accompanied by a decrease in Rm was investigated using the current-clamp technique. The result showed that cation channels coupled with NK-1 receptors on SMG cells were involved in generation of the SP-depolarization, and that the main charge carrier was the sodium ion.

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Animals Cricetinae Dose-Response Relationship, Drug Electric Impedance Electrophysiology Ganglia, Parasympathetic Male Membrane Potentials Patch-Clamp Techniques Receptors, Neurokinin-1 Sodium Channels Substance P Tachykinins Journal Article

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T Soejima, T Endoh, T Suzuki. 1998. Substance P-induced depolarization accompanied by a decrease in membrane input resistance in the hamster submandibular ganglion cell.. https://pubmed.ncbi.nlm.nih.gov/9667145/

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