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3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function.

R R Metzger·G R Hanson·J W Gibb·A E Fleckenstein
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Abstract

The acute effects of the amphetamine designer drug, 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'), on dopamine transporter function in rat striatum were investigated and compared to other psychostimulants known to influence monoaminergic systems. A single MDMA injection (10-20 mg/kg; s.c.) caused a dose-related decrease in [3H]dopamine uptake into striatal synaptosomes prepared 1 h after MDMA administration. This rapid effect on [3H]dopamine uptake returned to control levels 24 h after treatment. A single administration of other amphetamine analogs, such as methamphetamine (15 mg/kg; s.c.), p-chloroamphetamine (10 mg/kg; i.p.) or methcathinone (30 mg/kg; s.c.), also rapidly decreased striatal [3H]dopamine uptake. In contrast, a single or multiple administrations of cocaine (30 mg/kg; i.p.) had no effect on [3H]dopamine transport into striatal synaptosomes. These changes in dopamine transporter activity by the amphetamine analogs may occur via reactive oxygen species-mediated mechanisms.

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AnimalsCarrier ProteinsCocaineDopamineDopamine Plasma Membrane Transport ProteinsHallucinogensMaleMembrane GlycoproteinsMembrane Transport ProteinsMethamphetamineN-Methyl-3,4-methylenedioxyamphetamineNeostriatumNerve Tissue ProteinsPropiophenonesRatsRats, Sprague-DawleySynaptosomesComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R R Metzger, G R Hanson, J W Gibb, A E Fleckenstein. 1998-05-22. 3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function.. https://doi.org/10.1016/s0014-2999(98)00196-4

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