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PubMed · 9672235

A primer on HIV type 1-specific immune function and REMUNE.

R B Moss·W K Giermakowska·J R Savary·G Theofan·A E Daigle·S P Richieri·F C Jensen·D J Carlo
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Abstract

The ability to recognize HIV antigens is lost early in HIV-1 infection. Individuals with nonprogressive HIV disease have been observed to mount strong immune responses against the virus and have become a paradigm to emulate with immune-based therapies. Highly active antiviral drug therapy (HAART) has now become the standard of care for HIV-1-infected individuals. Because HIV-specific anergy occurs early in HIV infection, HAART initiated after primary infection may not reconstitute HIV-specific immune function. We have been investigating the effects of an immune-based therapy, called REMUNE, in HIV-1-seropositive individuals. REMUNE has been observed to stimulate HIV-1-specific immune function measured by delayed-type hypersensitivity, lymphocyte proliferation, Th1 cytokine, and beta-chemokine production. Multiple Phase II studies and a Phase III clinical end-point study are ongoing in thousands of seropositive individuals in order to test the clinical utility of REMUNE. The clinical testing of REMUNE and other promising immune-based therapies may provide additional treatment modalities useful in the chronic management of HIV-1.

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AIDS VaccinesAdjuvants, ImmunologicClinical Trials, Phase II as TopicDouble-Blind MethodHIV InfectionsHIV-1HumansImmunotherapyJournal ArticleReview

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R B Moss, W K Giermakowska, J R Savary, G Theofan, A E Daigle, S P Richieri, F C Jensen, D J Carlo. 1998. A primer on HIV type 1-specific immune function and REMUNE.. https://pubmed.ncbi.nlm.nih.gov/9672235/

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