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PubMed · 9679739

CA 125 elevations in patients with malignant lymphomas.

T Fehm·E Beck·T Valerius·M Gramatzki·W Jäger
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Abstract

Circulating CA 125 serum levels were measured in 60 patients with several hematological malignancies. Using 35 U/ml as cutoff level, elevated CA 125 concentrations were found in 3 of 18 patients with acute leukemia, 1 of 5 patients with chronic myelocytic leukemia, 2 of 9 patients with Hodgkin's lymphoma and in 14 of 28 patients with non-Hodgkin's lymphoma. None of the healthy control group had CA 125 serum levels above 35 U/ml. In patients with malignant lymphoma, elevated CA 125 serum concentrations were associated with abdominal involvement (p < 0.01). 15 of 19 patients with abdominal tumor masses had CA 125 concentrations above 35 U/ml, but only 1 of 18 patients with supradiaphragmatic involvement. Serial determinations of CA 125 were performed in 3 patients with malignant lymphoma during chemotherapy. Disease regression was associated with decreasing CA 125 serum levels. Thus, CA 125 may be a useful indicator of abdominal involvement in patients with malignant lymphoma. Moreover, serial CA 125 measurement may be of value in monitoring response to chemotherapy in these patients.

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Acute DiseaseAdultAgedAged, 80 and overBiomarkers, TumorCA-125 AntigenFemaleHodgkin DiseaseHumansLeukemiaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphomaLymphoma, Non-HodgkinMaleMiddle AgedJournal Article

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T Fehm, E Beck, T Valerius, M Gramatzki, W Jäger. 1998. CA 125 elevations in patients with malignant lymphomas.. https://doi.org/10.1159/000030019

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