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PubMed · 9680648

Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes.

J Cao·G D Cuny·J R Hauske
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Abstract

Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyclic alkenes with terminal aryl olefins was utilized for the construction of a combinatorial library containing highly functionalized cyclopentane derivatives. The technology described herein represents a convergent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds useful for exploratory medicinal chemistry.

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Chemistry, OrganicCyclopentanesDatabases, FactualIndicators and ReagentsMass SpectrometryModels, MolecularMolecular StructureStereoisomerismStructure-Activity RelationshipJournal Article

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J Cao, G D Cuny, J R Hauske. Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes.. https://doi.org/10.1023/a%3A1009663720800

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