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PubMed · 9682039

Nuclear structure--skeletal gene expression interrelationships.

G S Stein·A J van Wijnen·J L Stein·J B Lian
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Abstract

Using the osteocalcin gene as a paradigm for bone tissue-specific transcription, evidence is presented for functional linkage of nuclear architecture with developmental and steroid hormone-responsive control. The involvement of chromatin structure, nucleosome organization and the nuclear matrix is evaluated within the context of integrating regulatory signals that activate and/or suppress transcription of the osteocalcin gene. Mechanisms are evaluated which direct the bone and hematopoietic-specific acute myelogenous leukemia/core binding factor (AML/CBF) transcription factors to nuclear matrix-associated subnuclear domains that are competent to support expression.

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AnimalsBone and BonesCell Line, TumorCell NucleusChromatinCore Binding Factor alpha SubunitsGene Expression Regulation, DevelopmentalHumansNF-kappa BNuclear MatrixNuclear PoreNucleosomesOsteoblastsOsteocalcinOsteosarcomaPromoter Regions, GeneticProtein Structure, TertiaryReceptors, GlucocorticoidSignal TransductionTranscription FactorsTranscription, GeneticVitamin DVitamin D Response ElementJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review

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G S Stein, A J van Wijnen, J L Stein, J B Lian. 1998-08-01. Nuclear structure--skeletal gene expression interrelationships.. https://doi.org/10.2741/a328

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