Correlating structure and function in ATP-sensitive K+ channels.

F M Ashcroft; F M Gribble

doi:10.1016/s0166-2236(98)01225-9

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Correlating structure and function in ATP-sensitive K+ channels.

F M Ashcroft·F M Gribble

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Abstract

ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a regulatory subunit, the sulphonylurea receptor (SUR). This review focuses on the regulation of KATP channel activity by nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to Kir6.2 and which are conferred by association with SUR.

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ATP-Binding Cassette Transporters Adenosine Triphosphate Cells Diabetes Mellitus, Type 2 Genes, Regulator Genetic Linkage Hyperinsulinism In Vitro Techniques Models, Biological Nucleotides Potassium Channels Potassium Channels, Inwardly Rectifying Receptors, Drug Sodium-Potassium-Exchanging ATPase Sulfonylurea Compounds Sulfonylurea Receptors Journal Article Research Support, Non-U.S. Gov't Review

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F M Ashcroft, F M Gribble. 1998. Correlating structure and function in ATP-sensitive K+ channels.. https://doi.org/10.1016/s0166-2236(98)01225-9

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