Activation and repression in the nervous system.

R H Goodman; G Mandel

doi:10.1016/s0959-4388(98)80069-x

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Activation and repression in the nervous system.

R H Goodman·G Mandel

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Abstract

The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.

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CREB-Binding Protein Gene Expression Regulation Nervous System Physiological Phenomena Nuclear Proteins Signal Transduction Trans-Activators Transcriptional Activation Journal Article Review

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R H Goodman, G Mandel. 1998. Activation and repression in the nervous system.. https://doi.org/10.1016/s0959-4388(98)80069-x

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