PubMed · 9687739
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The cost effects.. https://pubmed.ncbi.nlm.nih.gov/9687739/
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Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor activation in human Valpha24JalphaQ T cell clones, DNA microarrays were used to quantitate changes in mRNA levels after anti-CD3 stimulation of clones derived from identical twins discordant for type 1 diabetes and IL-4 secretion. Activation resulted in significant modulation of 226 transcripts in the IL-4 secreting clone and 86 in the IL-4-null clone. Only 28 of these genes were in common. The differences observed suggest both ineffective differentiation of diabetic Valpha24JalphaQ T cells and a role for invariant T cells in the recruitment and activation of cells from the myeloid lineage.
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The perception that in type 2 diabetes mellitus the prognosis with regard to micro-angiopathic and macro-angiopathic complications significantly depends on the quality of metabolism and the level of the blood pressure, should prompt all of us to considerably intensify our efforts to ensure optimal treatment for the diabetic. For example, insulin will have to administered at an earlier time-point and to a much greater extent than formerly. In order to meet the objectives specified in the St. Vincent Declaration of 1989, not only close cooperations between family doctors and diabetologists in specialist practices and hospitals, but also comprehensive quality control measures will be needed. In new diabetes contracts, for example the interface model, attempts are being made to take account of these facts. The various tasks of family doctors and specialized diabetes practices are discussed on the basis of the interface model.