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Major histocompatibility complex-based suppression: a mechanism for T-cell control.

D W Gray
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Abstract

The crucial cell for immune system control is the T-cell. Current theories for T-cell control lack a credible mechanism for active down-regulation, because any mechanism that actively switches off T-cells must be secure from duplication by invading organisms. This hypothesis presents a system for T-cell control which is secure because it requires recognition of the highly polymorphic molecules of the MHC by the T-cell receptor as the down-regulatory mechanism, thus using the MHC as a form of individual security code.

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AnimalsDown-RegulationHumansImmune ToleranceLymphocyte ActivationMajor Histocompatibility ComplexModels, ImmunologicalT-LymphocytesJournal Article

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BibTeXRIS

D W Gray. 1998. Major histocompatibility complex-based suppression: a mechanism for T-cell control.. https://doi.org/10.1016/s0306-9877(98)90001-9

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