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PubMed · 9695187

Btk function in B cell development and response.

A B Satterthwaite·Z Li·O N Witte
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Abstract

Mutations in Bruton's tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their response to B cell antigen receptor (BCR) crosslinking depend on Btk. Btk integrates signals from multiple cell surface receptors, including BCR and G-protein coupled receptors. These Btk dependent signals control B cell proliferation and survival by mediating Ca2+ flux, activating JNK and p38 and inducing cell cycle regulatory genes.

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Agammaglobulinaemia Tyrosine KinaseAnimalsApoptosisB-LymphocytesCell SurvivalHumansMiceProtein-Tyrosine KinasesReceptors, Antigen, B-CellSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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A B Satterthwaite, Z Li, O N Witte. 1998. Btk function in B cell development and response.. https://doi.org/10.1006/smim.1998.0123

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