Proteolytic ratchets that control progression through mitosis.

F M Townsley; J V Ruderman

doi:10.1016/s0962-8924(98)01268-9

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Proteolytic ratchets that control progression through mitosis.

F M Townsley·J V Ruderman

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Abstract

A key player in mitotic progression is a cell-cycle-regulated ubiquitin-protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase-anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis.

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Anaphase-Promoting Complex-Cyclosome Fungal Proteins Ligases Mitosis Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases Ubiquitins Yeasts Journal Article Review

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F M Townsley, J V Ruderman. 1998. Proteolytic ratchets that control progression through mitosis.. https://doi.org/10.1016/s0962-8924(98)01268-9

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