Thiopentone and propofol: a compatible mixture?

H G Paw; M Garrood; A J Fillery-Travis; G T Rich

doi:10.1046/j.1365-2346.1998.00309.x

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Thiopentone and propofol: a compatible mixture?

H G Paw·M Garrood·A J Fillery-Travis·G T Rich

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Abstract

The physical compatibility of thiopentone and propofol mixtures was investigated. The investigations used were macroscopic and microscopic observations, zeta potential and oil droplet size measurements. There was no evidence of instability in the mixtures. The thiopentone-propofol mixture has the potential advantage of reducing the pain on injection, provides synergistic interaction, does not prolong recovery when used for induction of anaesthesia, may reduce the incidence of convulsions and is cost-effective.

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Anesthesia Recovery Period Anesthetics, Intravenous Chemical Phenomena Chemistry, Physical Cost-Benefit Analysis Drug Stability Drug Synergism Electric Conductivity Electrochemistry Emulsions Humans Incidence Injections, Intravenous Pain Propofol Seizures Thiopental Journal Article

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H G Paw, M Garrood, A J Fillery-Travis, G T Rich. 1998. Thiopentone and propofol: a compatible mixture?. https://doi.org/10.1046/j.1365-2346.1998.00309.x

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