G alpha q cDNA sequence from human platelets.

J Gabbeta; N Dhanasekaran; A K Rao

doi:10.1016/s0049-3848(98)00071-1

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G alpha q cDNA sequence from human platelets.

J Gabbeta·N Dhanasekaran·A K Rao

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Abstract

G-proteins play a major role in cell signaling and specific abnormalities in these proteins have been implicated in some diseases. Although, two human G alpha q coding sequences are published, they differ at functionally important regions. We have sequenced the human G alpha q cDNA synthesized from normal platelet mRNA by reverse transcription. Our results showed that the penultimate amino acid leucine is conserved in the human G alpha q sequence which has 94.4% identity in nucleotide sequence and 99.2% homology in amino acid sequence with murine sequence.

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Amino Acid Sequence Blood Platelets Cloning, Molecular DNA, Complementary GTP-Binding Proteins Humans Molecular Sequence Data Polymerase Chain Reaction Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J Gabbeta, N Dhanasekaran, A K Rao. 1998-07-01. G alpha q cDNA sequence from human platelets.. https://doi.org/10.1016/s0049-3848(98)00071-1

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