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PubMed · 9702077

[Leptin Receptor].

K Takaya·Y Ogawa·H Masuzaki·N Matsuoka·K Hosoda·K Nakao
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Abstract

Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus. Ob-R is a member of cytokine receptors and involves the JAK-STAT signal transduction system. We found Ob-R mutations in Zucker fatty rats and obese Koletsky rats and demonstrated that Ob-R dysfunction brings around hyperphagia and obesity. However we and others have not found any Ob-R mutation in human obese subjects.

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AnimalsCarrier ProteinsGene ExpressionHumansHyperphagiaLeptinMiceMutationObesityProtein-Tyrosine KinasesProteinsRatsRats, ZuckerReceptors, Cell SurfaceReceptors, LeptinSignal TransductionTrans-ActivatorsJournal ArticleReview

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K Takaya, Y Ogawa, H Masuzaki, N Matsuoka, K Hosoda, K Nakao. 1998. [Leptin Receptor].. https://pubmed.ncbi.nlm.nih.gov/9702077/

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