Aptamers as potential nucleic acid pharmaceuticals.

A D Ellington; R Conrad

doi:10.1016/s1387-2656(08)70052-8

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Aptamers as potential nucleic acid pharmaceuticals.

A D Ellington·R Conrad

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Abstract

In vitro selection is a technique for the isolation of nucleic acid ligands that can bind to proteins with high affinity and specificity, and has potential applications in the development of new pharmaceuticals. This review summarizes the protein targets that have successfully elicited nucleic acid binding species (also known as "aptamers") and explores examples of how they might be developed for clinical use. In particular, the use of aptamers for the alleviation of blood clotting and the treatment of AIDS are considered.

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Acquired Immunodeficiency Syndrome Anti-HIV Agents Base Sequence Binding Sites Drug Design Fibrinolytic Agents Genes, rev Humans Molecular Sequence Data Oligonucleotides RNA, Viral Thrombin Journal Article Research Support, Non-U.S. Gov't Review

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A D Ellington, R Conrad. 1995. Aptamers as potential nucleic acid pharmaceuticals.. https://doi.org/10.1016/s1387-2656(08)70052-8

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